DERLIN-1 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS11268R

Catalog No. 50-198-1218

Description

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

Specifications

• Antigen: DERLIN-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DERL1
• Gene Alias: 1110021N07Rik; AI195141; AW551338; Degradation in endoplasmic reticulum protein 1; Der1; DER-1; Der1-like domain family, member 1; Der1-like protein 1; DERL1; derlin 1; Derlin-1; DERtrin-1; UNQ243/PRO276
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 79139
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q9BUN8
• Gene Symbols: DERL1
• Immunogen: KLH conjugated synthetic peptide derived from human DERLIN-1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG