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Invitrogen™ Desmin Monoclonal Antibody (3-F7)
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Catalog No. PIMA544620
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Quantity:
100 μL
Catalog No. Quantity
PIMA544620 100 μL
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Catalog No. PIMA544620

Supplier: Invitrogen™ MA544620

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Description

Mouse Monoclonal Antibody

Desmin Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
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Specifications

Antigen Desmin
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3-F7
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene DES
Gene Accession No. P17661, P31001
Gene Alias CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Gene Symbols DES
Host Species Mouse
Immunogen Recombinant protein within human Desmin aa 300-470.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13346, 1674
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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