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Invitrogen™ Desmin Monoclonal Antibody (D9)
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Catalog No. MA106401
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100 μg
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Catalog No. Quantity
MA106401 100 μg
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Catalog No. MA106401 Supplier Invitrogen™ Supplier No. MA106401
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Description

Mouse Monoclonal Antibody

MA1-06401 detects desmin in human, mouse, rat, rabbits, pig, and chicken samples. MA1-06401 has sucessfully been used in Western blotting, and immunohistochemistry. By Western blotting, it detects a ~53 kDa protein representing desmin. The MA1-06401 immunogen is desmin isolated from human leiomyoma.

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmin
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone D9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene DES
Gene Accession No. P02540, P02542, P17661, P31001, P48675
Gene Alias CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Gene Symbols DES
Host Species Mouse
Immunogen Desmin isolated from human leiomyoma.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100328890, 13346, 1674, 395906, 396725, 64362
Target Species Human, Mouse, Rat, Rabbit, Pig, Chicken
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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