Invitrogen™ Desmocollin 2 Recombinant Rabbit Monoclonal Antibody (521)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA530497

Catalog No. PIMA530497

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Human DSC2.

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: Desmocollin 2
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q02487
• Gene Symbols: DSC2
• Immunogen: Recombinant Human DSC2 protein (Met1-Arg684).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA
• Clone: 521
• Conjugate: Unconjugated
• Gene: DSC2
• Gene Alias: ARVC10; ARVD10; ARVD11; AW228162; Cadherin family member 2; CDHF2; CDHF5; CDHF6; CMD1BB; desmocollin 2; desmocollin-2; Desmocollin-3; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; DG2; DGII/III; DSC2; Dsc2a; Dsc2b; DSC3; Epithelial type 2 desmocollin; HDGC; PVA
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1824
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid