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Invitrogen™ Desmoglein 3 Monoclonal Antibody (5G11)
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Catalog No. PIMA516025
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100 μL
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Catalog No. Quantity
PIMA516025 100 μL
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Catalog No. PIMA516025 Supplier Invitrogen™ Supplier No. MA516025
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Description

Mouse Monoclonal Antibody

Desmoglein 3 Monoclonal Antibody for Western Blot, IHC (P), ICC/IF, Flow, IP

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmoglein 3
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 5G11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Dsg3
Gene Accession No. P32926
Gene Alias 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; bal; balding; Cadherin family member 6; CDHF6; desmoglein 3; desmoglein-3; DKFZp686P23184; Dsg3; PVA
Gene Symbols Dsg3
Host Species Mouse
Immunogen Human Desmoglein 3 recombinant protein.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1830
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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