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Invitrogen™ Desmoglein 3 Monoclonal Antibody (5G11)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA516025
Description
Desmoglein 3 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow, IP, DB
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
Specifications
Desmoglein 3 | |
Monoclonal | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
P32926 | |
Dsg3 | |
Human Desmoglein 3 recombinant protein. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Dot Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
5G11 | |
Unconjugated | |
Dsg3 | |
130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; bal; balding; Cadherin family member 6; CDHF6; desmoglein 3; desmoglein-3; DKFZp686P23184; Dsg3; PVA | |
Mouse | |
Protein G | |
RUO | |
1830 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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