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Invitrogen™ Desmoglein 3 Polyclonal Antibody
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Catalog No. PIPA5121194
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100 μL
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PIPA5121194 100 μL
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Catalog No. PIPA5121194 Supplier Invitrogen™ Supplier No. PA5121194
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa, Mouse liver. The target is usually found in the following locations: Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome. Immunogen sequence: FGAATGVGIC SSGQSGTMRT RHSTGGTNKD YADGAISMNF LDSYFSQKAF ACAEEDDGQE ANDCLLIYDN EGADATGSPV GSVGCCSFIA DDLDDSFLDS LGPKFKKLAE ISLGVDGEGK EVQPPSKDSG YGIESCGHPI EVQQTGFVKC QTLSGSQGAS ALSTSGSVQP AVSIPDPLQH GNYLVTETYS ASGSLVQPST AGFDPLLTQN VIVTERVICP ISSVPGNLAG PTQLRGSHTM LCTEDPCSRL I.

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmoglein 3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Dsg3
Gene Accession No. P32926
Gene Alias 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; bal; balding; Cadherin family member 6; CDHF6; desmoglein 3; desmoglein-3; DKFZp686P23184; Dsg3; PVA
Gene Symbols Dsg3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 749-999 of human Desmoglein 3 (NP_001935.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1830
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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