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Invitrogen™ Desmoglein 3 Recombinant Mouse Monoclonal Antibody (4C2)
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Catalog No. FEMA549981
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100 μL
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FEMA549981 100 μL
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Catalog No. FEMA549981 Supplier Invitrogen™ Supplier No. MA549981
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Description

Mouse Recombinant Monoclonal Antibody

Desmoglein 3 Recombinant Monoclonal Antibody for ELISA

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
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Specifications

Antigen Desmoglein 3
Applications ELISA, Neutralization
Classification Recombinant Monoclonal
Clone 4C2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
Gene Dsg3
Gene Accession No. O35902, P32926
Gene Alias 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; bal; balding; Cadherin family member 6; CDHF6; desmoglein 3; desmoglein-3; DKFZp686P23184; Dsg3; PVA
Gene Symbols Dsg3
Host Species Mouse
Immunogen Recombinant Human DSG3 protein.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13512, 1830
Target Species Human, Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG1
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