Dexamethasone 21-phosphate disodium salt, 98%

Description

Dexamethasone 21-phosphate disodium salt, CAS # 2392-39-4, is a synthetic adrenal glucocorticoid with potent anti-inflammatory activity. | CAS: 2392-39-4 | C22H28FNa2O8P | 516.41 g/mol

Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Dexamethasone 21-phosphate disodium salt is a sodium phosphate salt form of dexamethasone, considered to be a synthetic adrenal glucocorticoid with anti-inflammatory activity

Application

• Dexamethasone 21-phosphate disodium salt binds to specific nuclear steroid receptors, interfering with NF-kB activation and apoptotic pathways
• It acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter
• It has been used as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models
• This compound is used to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs

Specifications

Chemical Identifiers

• CAS: 2392-39-4
• Molecular Formula: C22H28FNa2O8P
• Molecular Weight (g/mol): 516.41
• MDL Number: MFCD00079105
• InChI Key: PLCQGRYPOISRTQ-FCJDYXGNSA-L
• Synonym: dexamethasone sodium phosphate, dexamethasone 21-phosphate disodium salt, dalalone, dexadreson, dexagro, megacort, soldesam, spersadox, decdan, solu-decadron
• PubChem CID: 16961
• ChEBI: CHEBI:4462
• IUPAC Name: disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

• Melting Point: 233°C to 240°C
• Color: White
• Quantity: 1 g
• Beilstein: 6473066
• Merck Index: 142943
• Solubility Information: Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
• Formula Weight: 516.4
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: Dexamethasone 21-phosphate disodium salt

Safety and Handling

Hazard Category	Acute toxicity (category 4), Reproductive toxicity (category 2), Specific target organ toxicity after repeated exposure (category 2)
Hazard Statement	Harmful if swallowed, Suspected of damaging the unborn child, May cause damage to organs through prolonged or repeated exposure
EINECSNumber	219-243-0
RTECSNumber	TU4056000
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only