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Invitrogen™ DFNA5 Polyclonal Antibody
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Catalog No. PIPA5109333
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PIPA5109333 100 μL
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Catalog No. PIPA5109333 Supplier Invitrogen™ Supplier No. PA5109333
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Description

Rabbit Polyclonal Antibody

Positive Control: SiHa cell lysates, rat testis tissue, human thyroid gland tissue, human breast tissue, mouse small intestine tissue.

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein that is expressed in cochlea tissue, as well as in placenta, brain, heart, liver, lung and pancreas as two alternatively spliced isoforms, designated short and long. Defects in the gene encoding DFNA5 are the cause of non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of sensorineural hearing loss that results from damage to one of various structures that receive sound information in the brain. The gene encoding DFNA5 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DFNA5
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Gsdme
Gene Accession No. O60443
Gene Alias 2310037D07Rik; 4932441K13Rik; deafness, autosomal dominant 5; deafness, autosomal dominant 5 (human); deafness, autosomal dominant 5 homolog; Dfna5; DFNA5, deafness associated tumor suppressor; Dfna5h; EG14210; Fin15; Gasdermin-E; Gasdermin-E, C-terminal; Gasdermin-E, N-terminal; GSDME; GSDME-CT; GSDME-NT; ICERE1; ICERE-1; Inversely correlated with estrogen receptor expression 1; nonsyndromic hearing impairment protein; non-syndromic hearing impairment protein 5; Non-syndromic hearing impairment protein 5 homolog
Gene Symbols Gsdme
Host Species Rabbit
Immunogen Recombinant protein within Human DFNA5/GSDME aa 1-220.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1687
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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