Invitrogen™ DFNA5 Polyclonal Antibody

Catalog No.	Quantity
PIPA582429	100 μL

Catalog No. PIPA582429 Supplier Invitrogen™ Supplier No. PA582429

Description

Rabbit Polyclonal Antibody

Immunogen sequence: VLFDDELLMV LEPVCDDLVS GLSPTVAVLG ELKPRQQQDL VAFLQLVGCS LQGGCPGPED AGSKQLFMTA YFLVSALAEM PDSAAALLGT CCKLQIIPTL CHLLRALSDD GVSDLEDPTL TPLKDTERFG IVQRLFASAD ISLERLKSSV Highest antigen sequence indentity to the following orthologs: Rat - 67%, Mouse - 66%.

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein that is expressed in cochlea tissue, as well as in placenta, brain, heart, liver, lung and pancreas as two alternatively spliced isoforms, designated short and long. Defects in the gene encoding DFNA5 are the cause of non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of sensorineural hearing loss that results from damage to one of various structures that receive sound information in the brain. The gene encoding DFNA5 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

Specifications

• Antigen: DFNA5
• Applications: Western Blot, Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Gsdme
• Gene Accession No.: O60443
• Gene Alias: 2310037D07Rik; 4932441K13Rik; deafness, autosomal dominant 5; deafness, autosomal dominant 5 (human); deafness, autosomal dominant 5 homolog; Dfna5; DFNA5, deafness associated tumor suppressor; Dfna5h; EG14210; Fin15; Gasdermin-E; Gasdermin-E, C-terminal; Gasdermin-E, N-terminal; GSDME; GSDME-CT; GSDME-NT; ICERE1; ICERE-1; Inversely correlated with estrogen receptor expression 1; nonsyndromic hearing impairment protein; non-syndromic hearing impairment protein 5; Non-syndromic hearing impairment protein 5 homolog
• Gene Symbols: Gsdme
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human DFNA5. Recombinant protein control fragment (Product #RP-102091).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1687
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG