Invitrogen™ DGKD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA545784

Catalog No. PIPA545784

Description

Peptide sequence: KRSRSGKFRL VTKFKKEKNN KNKEAHSSLG APVHLWGTEE VAAWLEHLSL Sequence homology: Dog: 79%; Guinea Pig: 93%; Human: 100%; Mouse: 92%; Rabbit: 86%; Rat: 100%.

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK-alpha influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-gamma encodes full-length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK-delta is most abundant in skeletal muscle. DGK-epsilon shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK-theta is most abundant in the cerebellum and hippocampus. DGK-iota is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3-prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK-eta is closely related to DGK-delta. DGK-zeta is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.

Specifications

• Antigen: DGKD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DGKD
• Gene Alias: 130 kDa diacylglycerol kinase; AI841987; D330025K09; DAG kinase delta; DGK delta; DGKD; dgkd-2; DGKdelta; DGK-delta; Diacylglycerol kinase delta; diacylglycerol kinase, delta; diacylglycerol kinase, delta 130kDa; Diglyceride kinase; diglyceride kinase delta; EC 2.7.1.107; FLJ26930; hypothetical protein LOC513389; KIAA0145; RGD1563309
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8527
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q16760
• Gene Symbols: DGKD
• Immunogen: Synthetic peptide directed towards the C-terminal of human DGKD (aa 1110-1159).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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