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Invitrogen™ DGKD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575256

Catalog No. PIPA575256


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Description

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK-alpha influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-gamma encodes full-length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK-delta is most abundant in skeletal muscle. DGK-epsilon shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK-theta is most abundant in the cerebellum and hippocampus. DGK-iota is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3-prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK-eta is closely related to DGK-delta. DGK-zeta is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DGKD
Polyclonal
Unconjugated
DGKD
130 kDa diacylglycerol kinase; AI841987; D330025K09; DAG kinase delta; DGK delta; DGKD; dgkd-2; DGKdelta; DGK-delta; Diacylglycerol kinase delta; diacylglycerol kinase, delta; diacylglycerol kinase, delta 130kDa; Diglyceride kinase; diglyceride kinase delta; EC 2.7.1.107; FLJ26930; hypothetical protein LOC513389; KIAA0145; RGD1563309
Rabbit
Antigen affinity chromatography
RUO
227333, 368088, 8527
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
E9PUQ8, Q16760
DGKD
Synthetic peptide corresponding to amino acids 34-88 of Human DGKD.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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