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Invitrogen™ DGKE Polyclonal Antibody
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Catalog No. PIPA553558
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100 μL
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PIPA553558 100 μL
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Catalog No. PIPA553558 Supplier Invitrogen™ Supplier No. PA553558
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RDTDLFSQPT YCCVCAQHIL QGAFCDCCGL RVDEGCLRKA DKRFQCKEIM LKNDTKVLDA MPHHWIRGNV PLCSYCMVCK QQCGCQPKLC DYRCIWCQKT VHDECMKNSL KNEKCDFGEF KNLIIPPSYL Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.

Diacylglycerol (DAG) influences numerous cell signaling cascades by functioning as an intracellular, allosteric activator of protein kinase C (PKC), and as a potent activator of guanine nucleotide exchange factors. In order to maintain cellular homeostasis, intracellular DAG levels are tightly regulated by diacylglycerol kinases (DGKs, DAGKs), which phosphorylate DAG to phosphatidic acid, thus removing DAG. Human DGK-alpha (80 kDa), -beta (90 kDa), and - gamma (90 kDa) have calcium-binding EF-hand motifs at their N termini and are classified as type I DGKs. Human DGK- delta (130 kDa) and DGK-i (130 kDa) contain N-terminal pleckstrin homology (PH) domains and are classified as type II. Human DGK- epsilon (64 kDa) contains no identifiable regulatory domains and is classified as a type III DGK. Human DGK- zeta (104 kDa) and -iota (130 kDa) possess C-terminal ankyrin repeats and are classified as type IV DGKs. Human DGK-theta (110 kDa) contains 3 cysteine-rich domains and a PH domain and is classified as a type V DGK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DGKE
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Dgke
Gene Accession No. P52429
Gene Alias AHUS7; C87606; DAG kinase epsilon; DAGK5; DAGK6; DGK; DGKE; DGK-epsilon; Diacylglycerol kinase epsilon; diacylglycerol kinase, epsilon; diacylglycerol kinase, epsilon 64kDa; diglyceride kinase epsilon; EC 2.7.1.107; NPHS7
Gene Symbols Dgke
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DGKE. Recombinant protein control fragment (Product #RP-90372).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8526
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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