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Invitrogen™ DGKI Polyclonal Antibody
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Catalog No. PIPA5106463
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100 μL
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PIPA5106463 100 μL
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Catalog No. PIPA5106463 Supplier Invitrogen™ Supplier No. PA5106463
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DGKI.

Diacylglycerol (DAG) influences numerous cell signaling cascades by functioning as an intracellular, allosteric activator of protein kinase C (PKC), and as a potent activator of guanine nucleotide exchange factors. In order to maintain cellular homeostasis, intracellular DAG levels are tightly regulated by diacylglycerol kinases (DGKs, DAGKs), which phosphorylate DAG to phosphatidic acid, thus removing DAG. Human DGK-α (80 kDa), -β (90 kDa), and - γ (90 kDa) have calcium-binding EF-hand motifs at their N termini and are classified as type I DGKs. Human DGK-δ (130 kDa) and DGK-ι (130 kDa) contain N-terminal pleckstrin homology (PH) domains and are classified as type II. Human DGK-epsilon (64 kDa) contains no identifiable regulatory domains and is classified as a type III DGK. Human DGK-Ω (104 kDa) and -iota (130 kDa) possess C-terminal ankyrin repeats and are classified as type IV DGKs. Human DGK-θ (110 kDa) contains 3 cysteine-rich domains and a PH domain and is classified as a type V DGK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DGKI
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DGKI
Gene Accession No. O75912
Gene Alias C130010K08Rik; DAG kinase iota; DGKI; DGK-iota; Diacylglycerol kinase iota; diacylglycerol kinase iota-3; diacylglycerol kinase, iota; Diglyceride kinase; diglyceride kinase iota; EC 2.7.1.107; rDGKi-3
Gene Symbols DGKI
Host Species Rabbit
Immunogen A synthesized peptide derived from human DGKI(Accession O75912), corresponding to amino acid residues A1003-Y1053.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 320127, 688705, 9162
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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