Invitrogen™ DGKQ Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101127

Catalog No. PIPA5101127

Description

Antibody detects endogenous levels of total DAGK.

Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-theta is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-theta co-localizes with phosphatidylinositol 4, 5-bisphosphate (PIP(2)). DGK-theta is the isoform responsive to alpha-Thrombin stimulation.

Specifications

• Antigen: DGKQ
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DGKQ
• Gene Alias: 110kDa; DAG kinase theta; DAGK; Dagk4; DAGK7; Dgk theta; Dgkd; DGKQ; DGK-theta; Diacylglycerol kinase theta; diacylglycerol kinase, delta (110 kDa); diacylglycerol kinase, theta; diacylglycerol kinase, theta 110kDa; diglyceride kinase theta; testis tissue sperm-binding protein Li 38a
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 110524, 1609
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P52824, Q6P5E8
• Gene Symbols: DGKQ
• Immunogen: A synthesized peptide derived from human DGKQ(Accession P52824), corresponding to amino acid residues Q800-V850.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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