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Invitrogen™ DGUOK Polyclonal Antibody
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Catalog No. PIPA563419
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100 μL
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PIPA563419 100 μL
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Catalog No. PIPA563419 Supplier Invitrogen™ Supplier No. PA563419
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EAWLIHKTTK LHFEALMNIP VLVLDVNDDF SEEVTKQEDL MREVNTFVKN Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 64%.

Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DGUOK
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DGUOK
Gene Accession No. Q16854
Gene Alias deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; dGK; dGK1; dGK2; dGK3; DGUOK; MTDPS3
Gene Symbols DGUOK
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DGUOK. Recombinant protein control fragment (Product #RP-103703).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1716
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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