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Invitrogen™ DGUOK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109631

Catalog No. PIPA5109631


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Description

Description

Immunogen sequence: RLSIEGNIAV GKSTFVKLLT KTYPEWHVAT EPVATWQNIQ AAGTQKACTA QSLGNLLDMM YREPARWSYT FQTFSFLSRL KVQLEPFPEK LLQARKPVQI FERSVYSDRY IFAKNLFENG SLSDIEWHIY QDWHSFLLWE FASRITLHGF IYLQASPQVC LKRLYQRARE EEKGIELAYL EQLHGQHEAW LIHKTTKLHF EALMNIPVLV LDVNDDFSEE VTKQEDLMRE VNTFVKNL.

Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DGUOK
Polyclonal
Unconjugated
DGUOK
deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; dGK; dGK1; dGK2; dGK3; DGUOK; MTDPS3
Rabbit
Affinity chromatography
RUO
1716, 27369, 297389
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ELISA, Western Blot
0.85 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q16854, Q9QX60
DGUOK
Recombinant fusion protein containing a sequence corresponding to amino acids 40-277 of human DGUOK (NP_550438.1).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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