Invitrogen™ DHCR24 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527944

Catalog No. PIPA527944

Description

Recommended positive controls: A431, H1299, mouse brain. Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (82%), Xenopus laevis (81%), Pig (95%), Chicken (80%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Specifications

• Antigen: DHCR24
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dhcr24
• Gene Alias: 2310076D10Rik; 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol delta-24-reductase; 5830417J06Rik; DCE; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; DHCR24; Diminuto/dwarf1 homolog; KIAA0018; mKIAA0018; Nbla03646; seladin 1; SELADIN1; seladin-1; selective AD indicator 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1718, 298298
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.29 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q15392, Q5BQE6
• Gene Symbols: Dhcr24
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Seladin 1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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