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Invitrogen™ DHCR24 Polyclonal Antibody
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Catalog No. PIPA584579
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100 μL
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PIPA584579 100 μL
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Catalog No. PIPA584579 Supplier Invitrogen™ Supplier No. PA584579
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Rabbit Polyclonal Antibody

Immunogen sequence: ILEVDTKKQI VRVEPLVTMG QVTALLTSIG WTLPVLPELD DLTVGGLIMG TGIESSSHKY GLFQHICTAY ELVLADGSFV RCTPSENSDL FYAVPWSCGT LGFLVAAEIR IIPAKKYVKL RFEPVRGLEA ICAKFTHESQ Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 96%.

DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DHCR24
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Dhcr24
Gene Accession No. Q15392
Gene Alias 2310076D10Rik; 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol delta-24-reductase; 5830417J06Rik; DCE; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; DHCR24; Diminuto/dwarf1 homolog; KIAA0018; mKIAA0018; Nbla03646; seladin 1; SELADIN1; seladin-1; selective AD indicator 1
Gene Symbols Dhcr24
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DHCR24. Recombinant protein control fragment (Product #RP-103483).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1718
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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