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Invitrogen™ DHCR24 Polyclonal Antibody
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Catalog No. PIPA592446
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100 μL
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PIPA592446 100 μL
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Catalog No. PIPA592446 Supplier Invitrogen™ Supplier No. PA592446
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AEIRIIPAKK YVKLRFEPVR GLEAICAKFT HESQRQENHF VEGLLYSLDE AVIMTGVMTD EAEPSKLNSI GNYYKPWFFK HVENYLKTNR EGLEYIPLRH YYHRHTRSIF WELQDIIPFG NNPIFRYLFG WMVPPKISLL KLTQGETLRK LYEQHHVVQD MLVPMKCLQQ ALHTFQNDIH VYPIWLCPFI LPSQPGLVHP KGNEAELYID IGAYGEPRVK HFEARSCMRQ LEKFVRSVHG FQMLYADCYM NREEFWEMFD GSLYHKLREK LGCQDAFPEV YDKICKAARH; Positive Samples: U-87MG, HT-29, PC-12, NCI-H460; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass membrane protein.

DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DHCR24
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.42 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Dhcr24
Gene Accession No. Q15392, Q5BQE6, Q8VCH6
Gene Alias 2310076D10Rik; 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol delta-24-reductase; 5830417J06Rik; DCE; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; DHCR24; Diminuto/dwarf1 homolog; KIAA0018; mKIAA0018; Nbla03646; seladin 1; SELADIN1; seladin-1; selective AD indicator 1
Gene Symbols Dhcr24
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_0555771).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1718, 298298, 74754
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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