Invitrogen™ DHH Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547229

Catalog No. PIPA547229

Description

In Western blots, less than 1% cross-reactivity with recombinant mouse (rm) Dhh N-terminus peptide (aa 23-198), rmShh C-terminus peptide (aa 199-437), and rmIhh C-terminus peptide (aa 241-449) is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signaling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.

Specifications

• Antigen: DHH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dhh
• Gene Alias: C78960; desert hedgehog; desert hedgehog protein; Desert hedgehog protein C-product; Desert hedgehog protein N-product; Dhh; GDXYM; HHG-3; SRXY7
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13363
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q61488
• Gene Symbols: Dhh
• Immunogen: E. coli-derived recombinant mouse Desert Hedgehog/Dhh C-Terminus Cys199-Gly396.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG