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Invitrogen™ H3K9me2S10phK27me2S28ph Monoclonal Antibody (51TA-2H12)

Catalog No. PIMA3065
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PIMA3065 50 μL
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Catalog No. PIMA3065 Supplier Invitrogen™ Supplier No. MA3065

Description

Mouse Monoclonal Antibody

MA3-065 detects dimethyl-phospho-histone H3 Lys9/Lys27 pSer10/pSer28 in human samples and has successfully been used in western blot and immunoprecipitation applications. The MA3-065 immunogen is a synthetic peptide conjugated to ovalbumin corresponding to residues 180-195 of human TAF10 and only recognizes phosphorlayted pSer10 or pSer28 of Histone H3 when the adjacent Lys is dimethylated.

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen H3K9me2S10phK27me2S28ph
Applications ChIP Assay, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 51TA-2H12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.05% sodium azide
Gene H3C1
Gene Accession No. P68431, Q71DI3
Gene Alias Di histone H3/c; dimethyl H3; di-methyl H3; Dimethyl Histone H3; di-methyl histone H3; Di-Methyl-Phospho-H3 K9 K27 S10 S28; Di-Methyl-Phospho-H3 Lys9 Lys27 Ser10 Ser28; Di-Methyl-Phospho-Histone H3 K9 K27 S10 S28; Di-Methyl-Phospho-Histone H3 Lys9 Lys27 Ser10 Ser28; H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3C; H3 K9me2S10phK27me2S28ph; H3.2; H3.3A; H3.3B; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-3A; H3-3B; H3a; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3F1K; H3F2; H3F3; H3F3A; H3F3B; H3F3C; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3k27; H3K27me2; H3K9; H3K9me2; H3K9me3S10phK27me3S28ph; H3K9me3S10pK27me3S28p; H3Lys9me3Ser10phLys27me3Ser28ph; H3Lys9me3Ser10pLys27me3Ser28p; H3s10; H3S10ph; H3S28; H3S28ph; HIST1H3A; HIST1H3B; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST2H3A; HIST2H3C; HIST2H3D; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3a; histone 2, H3c; Histone 3; histone cluster 1, H3a; histone cluster 1, H3b; histone cluster 1, H3f; histone cluster 1, H3h; histone cluster 2, H3a; histone cluster 2, H3c; Histone H3; histone H3.1; Histone H3.2; histone H3.3; Histone H3.3C; histone H3.5; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; histone H3/l; Histone H3/m; histone H3/o; Histone H3K27; Histone H3K27me2; Histone H3K9; Histone H3K9me2; Histone H3S10; Histone H3S10ph; Histone H3S28; Histone H3S28ph; histone variant H3.5; methyl Histone 3; methyl Histone H3; phospho Histone 3; phospho Histone H3; PP781
Gene Symbols H3C1, H3C10, H3C12, H3C14, H3C15, H3C2, H3C7
Host Species Mouse
Immunogen Ovalbumin conjugated synthetic peptide (ASGSSRSKS[dimethyl-K]DRKYTLC) correspeonding to aa 180-195 of human TAF10.
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 126961, 333932, 8350, 8356, 8357, 8358, 8968
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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