Invitrogen™ H3K9me2S10ph Monoclonal Antibody (6HH3-2C5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA3064

Catalog No. PIMA3064

Description

MA3-064 detects dimethyl-phospho- histone H3 Lys9 pSer10 in human samples and has successfully been used in western blot and immunoprecipitation applications. The MA3-064 immunogen is a synthetic peptide conjugated to ovalbumin corresponding to residues 7-20 of Human Histone H3, which is highly conserved across multiple species.

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

Specifications

• Antigen: H3K9me2S10ph
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.05% sodium azide
• Gene Accession No.: P68431, Q71DI3
• Gene Symbols: H3C1, H3C10, H3C12, H3C14, H3C15, H3C2, H3C7
• Immunogen: Ovalbumin conjugated synthetic peptide (AR[dimethyl-K][phospho-S]TGGAPRKQLC) correspeonding to aa 7-20 of histone H3.
• Regulatory Status: RUO
• Gene ID (Entrez): 126961, 333932, 8350, 8356, 8357, 8358, 8968
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ChIP Assay, Immunoprecipitation, Western Blot
• Clone: 6HH3-2C5
• Conjugate: Unconjugated
• Gene: H3C15
• Gene Alias: Di histone H3/c; dimethyl H3; di-methyl H3; Dimethyl Histone H3; di-methyl histone H3; Di-Methyl-Phospho-H3 K9 S10; Di-Methyl-Phospho-H3 Lys9 Ser10; Di-Methyl-Phospho-Histone H3 K9 S10; Di-Methyl-Phospho-Histone H3 Lys9 Ser10; H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3C; H3 K9me2S10ph; H3.2; H3.3A; H3.3B; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-3A; H3-3B; H3a; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3F1K; H3F2; H3F3; H3F3A; H3F3B; H3F3C; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3K9; H3K9me2; H3K9me2S10p; H3Lys9me2Ser10p; H3Lys9me2Ser10ph; H3s10; H3S10ph; HIST1H3A; HIST1H3B; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST2H3A; HIST2H3C; HIST2H3D; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3a; histone 2, H3c; Histone 3; histone cluster 1, H3a; histone cluster 1, H3b; histone cluster 1, H3f; histone cluster 1, H3h; histone cluster 2, H3a; histone cluster 2, H3c; Histone H3; histone H3.1; Histone H3.2; histone H3.3; Histone H3.3C; histone H3.5; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; histone H3/l; Histone H3/m; histone H3/o; Histone H3K9; Histone H3K9me2; Histone H3S10; Histone H3S10ph; histone variant H3.5; methyl Histone 3; methyl Histone H3; phospho Histone 3; phospho Histone H3; PP781
• Host Species: Mouse
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1