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Invitrogen™ DIABLO Monoclonal Antibody (78-1-118)
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Catalog No. AMPA6846
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200 μL
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Catalog No. Quantity
AMPA6846 200 μL
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Catalog No. AMPA6846 Supplier Invitrogen™ Supplier No. MA116846
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Description

Mouse Monoclonal Antibody

Suggested positive control: 293 whole cell lysate.

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
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Specifications

Antigen DIABLO
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 78-1-118
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.1% sodium azide
Gene DIABLO
Gene Accession No. Q9JIQ3, Q9NR28
Gene Alias 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
Gene Symbols DIABLO
Host Species Mouse
Immunogen Recombinant mature human Smac (lacks amino acids 1-55 present in Smac precursor).
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 288753, 56616, 66593
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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