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Invitrogen™ DIABLO Monoclonal Antibody (8H5AB2)
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Catalog No. A21986
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100 μg
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Catalog No. Quantity
A21986 100 μg
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Catalog No. A21986 Supplier Invitrogen™ Supplier No. A21986
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Description

Mouse Monoclonal Antibody

DIABLO Monoclonal Antibody for Western Blot

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
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Specifications

Antigen DIABLO
Applications Western Blot
Classification Monoclonal
Clone 8H5AB2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation HEPES buffered saline with 0.02% sodium azide
Gene DIABLO
Gene Accession No. Q9NR28
Gene Alias 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
Gene Symbols DIABLO
Host Species Mouse
Immunogen Recombinant SMAC, TIM22 proteins., TIM22 proteins
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56616
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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