Invitrogen™ DIABLO Monoclonal Antibody (SMAC 17 1-87)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA1936

Catalog No. AMP936

Description

MA1-936 detects Smac/DIABLO from human, mouse and rat tissues. MA1-936 has been successfully used in Immunoprecipitation, Western blot, Immunohistochemistry (paraffin), Immunofluorescence and immunocytochemistry. By Western blot it detects a 25-kDa band representing Smac/DIABLO. MA1-936 antigen is C-term His tagged recombinant human Smac/DIABLO.

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).

Specifications

• Antigen: DIABLO
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q9JIQ3, Q9NR28
• Gene Symbols: DIABLO
• Immunogen: C-Terminal His tagged recombinant human Smac/DIABLO.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: SMAC 17 1-87
• Conjugate: Unconjugated
• Gene: DIABLO
• Gene Alias: 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 288753, 56616, 66593
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov