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Invitrogen™ DIABLO Monoclonal Antibody (SMAC 17 1-87)
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Catalog No. AMP936
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100 μg
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Catalog No. Quantity
AMP936 100 μg
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Catalog No. AMP936 Supplier Invitrogen™ Supplier No. MA1936
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Description

Mouse Monoclonal Antibody

MA1-936 detects Smac/DIABLO from human, mouse and rat tissues. MA1-936 has been successfully used in Immunoprecipitation, Western blot, Immunohistochemistry (paraffin), Immunofluorescence and immunocytochemistry. By Western blot it detects a 25-kDa band representing Smac/DIABLO. MA1-936 antigen is C-term His tagged recombinant human Smac/DIABLO.

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
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Specifications

Antigen DIABLO
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone SMAC 17 1-87
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene DIABLO
Gene Accession No. Q9JIQ3, Q9NR28
Gene Alias 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
Gene Symbols DIABLO
Host Species Mouse
Immunogen C-Terminal His tagged recombinant human Smac/DIABLO.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 288753, 56616, 66593
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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