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Invitrogen™ DIABLO Polyclonal Antibody
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Catalog No. PIPA519975
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100 μg
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Catalog No. Quantity
PIPA519975 100 μg
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Catalog No. PIPA519975 Supplier Invitrogen™ Supplier No. PA519975
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~25kDa. A suggested positive control is mouse heart tissue lysate. PA5-19975 can be used with blocking peptide PEP-0100.

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
TRUSTED_SUSTAINABILITY

Specifications

Antigen DIABLO
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene DIABLO
Gene Accession No. Q9JIQ3, Q9NR28
Gene Alias 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
Gene Symbols DIABLO
Host Species Rabbit
Immunogen A 16 amino acid peptide near the carboxy terminus of murine Smac.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 288753, 56616, 66593
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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