Invitrogen™ DIABLO Recombinant Rabbit Monoclonal Antibody (0W1K4)

Catalog No.	Quantity
PIMA538181	100 μL

Catalog No. PIMA538181 Supplier Invitrogen™ Supplier No. MA538181

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: SP2/0, HeLa, MCF7, C2C12, Jurkat, C6, Mouse heart, Rat lung, Rat testis Immunogen sequence: AVPIAQKSEP HSLSSEALMR RAVSLVTDST STFLSQTTYA LIEAITEYTK AVYTLTSLYR QYTSLLGKMN SEEEDEVWQV IIGARAEMTS KHQEYLKLET TWMTAVGLSE MAAEAAYQTG ADQASITARN HIQLVKLQVE EVHQLSRKAE TKLAEAQIEE LRQKTQEEGE ERAESEQEAY LRED.

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).

Specifications

• Antigen: DIABLO
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 0W1K4
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene: DIABLO
• Gene Accession No.: Q9JIQ3, Q9NR28
• Gene Alias: 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
• Gene Symbols: DIABLO
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_0639401).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 288753, 56616, 66593
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov