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Invitrogen™ Dicer Monoclonal Antibody (CL0378)
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Catalog No. PIMA531353
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100 μL
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Catalog No. Quantity
PIMA531353 100 μL
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Catalog No. PIMA531353 Supplier Invitrogen™ Supplier No. MA531353
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Description

Mouse Monoclonal Antibody

Immunogen sequence: PTDADSAYCV LPLNVVNDSS TLDIDFKFME DIEKSEARIG IPSTKYTKET PFVFKLEDYQ DAVIIPRYRN FDQPHRFYVA DVYTDLTPLS KFPSPEYETF AEYYKTKYNL DLTNLNQPLL DVDHTSSRLN LLTPRHLNQK GKALPLSSAE KRKAKWESLQ NKQILVPELC AIHPIPASLW RKAVCLPSIL YRLH Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.

Dicer is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a means to specifically regulate the expression of target genes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dicer
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL0378
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DICER1
Gene Accession No. Q9UPY3
Gene Alias 1110006F08Rik; D12Ertd7e; DCR; DCR1; DCR-1; Dicer; dicer 1 ribonuclease III; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease III; dicer 1, ribonuclease type III; Dicer1; Dicer1, Dcr-1 homolog; Dicer1e; double-strand-specific ribonuclease mDCR-1; endoribonuclease Dicer; Helicase MOI; helicase with RNAse motif; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928; mKIAA0928; MNG1; RMSE2
Gene Symbols DICER1
Host Species Mouse
Immunogen Recombinant protein fragment of Human DICER1 (Product #RP-88877)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23405
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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