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Invitrogen™ Dicer Polyclonal Antibody
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Catalog No. PIPA5115124
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PIPA5115124 100 μL
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Catalog No. PIPA5115124 Supplier Invitrogen™ Supplier No. PA5115124
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Dicer.

Dicer is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a means to specifically regulate the expression of target genes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dicer
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene DICER1
Gene Accession No. Q8R418, Q9UPY3
Gene Alias 1110006F08Rik; D12Ertd7e; DCR; DCR1; DCR-1; Dicer; dicer 1 ribonuclease III; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease III; dicer 1, ribonuclease type III; Dicer1; Dicer1, Dcr-1 homolog; Dicer1e; double-strand-specific ribonuclease mDCR-1; endoribonuclease Dicer; Helicase MOI; helicase with RNAse motif; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928; mKIAA0928; MNG1; RMSE2
Gene Symbols DICER1
Host Species Rabbit
Immunogen A synthesized peptide derived from human DICER1(Accession Q9UPY3), corresponding to amino acid residues K1516-L1566.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 192119, 23405, 299284
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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