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MilliporeSigma™ dimethyl-Histone H3 (Lys4), Rabbit, Alexa Fluor 555, Polyclonal,

Catalog No. 07030AF555 Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Alexa Fluor 555
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Catalog No. Quantity Conjugate
07030AF555 100 μL Alexa Fluor 555
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Catalog No. 07030AF555 Supplier MilliporeSigma™ Supplier No. 07030AF555
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Description

Rabbit Polyclonal Antibody

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the &primebeads on a string&prime structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone H3 variants (H3.1, H3.2 and H3.3) have been implicated in the epigenetic memory of cellular state. Genome-wide patterns of H3 are dependent on amino acid sequence and change with cellular differentiation at developmentally regulated loci.
TRUSTED_SUSTAINABILITY

Specifications

Antigen dimethyl-Histone H3 (Lys4)
Applications Immunocytochemistry
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Alexa Fluor 555
Formulation Purified rabbit polyclonal antibody conjugate in PBS with 15mg/ml BSA and 0.1 % Sodium Azide.
Gene HIST1H3A, H3FA, HIST1H3B, H3FB, HIST1H3C, H3FC, HIST1H3D, H3FD, HIST1H3E, HIST1H3F, H3FF, HIST1H3G, HIST1H3H, H3FH, HIST1H3I, H3FI, HIST1H3J, H3FJ, H3FK, HIST3H3, H3FT, H3T
Gene Accession No. Q16695
Host Species Rabbit
Immunogen KLH-conjugated synthetic peptide (ART[Kme2]QTAR-GC) corresponding to amino acids 1-8 of human histone H3.
Purification Method Protein A Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_003484.1
Test Specificity Specificity of this polyclonal antibody toward histone H3 Lys4 dimethylation was demonstrated by dot blot analysis using the unconjugated antiserum (Mfr. No. 07-030).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
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For Research Use Only. Not for use in diagnostic procedures.

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