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Tocris Bioscience™ Dinaciclib

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Quantity:
10 mg
50 mg
Description
Dinaciclib is a potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9 activity in vitro (IC50 values are 1, 1, 3 and 4 nM, respectively). The compound inhibits DNA replication by blocking thymidine DNA incorporation in A2780 cells (IC50 = 4 nM). Dinaciclib induces regression of established solid tumors in mouse models and shows antiviral activity against SARS-CoV-2 in vitro (Vero E6, IC50 = 0.127 μM; A549-ACE2, IC50 = 0.032 μM).
Specifications
Specifications
Chemical Name or Material | (2 S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol |
CAS | 779353-01-4 |
Quantity | 50 mg |
Target | Cyclin-dependent Kinase Inhibitors |
Molecular Formula | C21H28N6O2 |
Purity | 0.98 |
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