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  5. Tocris Bioscience™ Dinaciclib

Tocris Bioscience™ Dinaciclib
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Catalog No. 733650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9

Dinaciclib is a potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9 activity in vitro (IC50 values are 1, 1, 3 and 4 nM, respectively). The compound inhibits DNA replication by blocking thymidine DNA incorporation in A2780 cells (IC50 = 4 nM). Dinaciclib induces regression of established solid tumors in mouse models and shows antiviral activity against SARS-CoV-2 in vitro (Vero E6, IC50 = 0.127 μM; A549-ACE2, IC50 = 0.032 μM).

Specifications

Chemical Name or Material (2 S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
CAS 779353-01-4
Quantity 50 mg
Target Cyclin-dependent Kinase Inhibitors
Molecular Formula C21H28N6O2
Purity 0.98
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