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Invitrogen™ DIO3 Polyclonal Antibody
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Catalog No. PIPA5103127
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PIPA5103127 100 μL
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Catalog No. PIPA5103127 Supplier Invitrogen™ Supplier No. PA5103127
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DIO3.

DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DIO3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DIO3
Gene Accession No. P49897, P55073, Q91ZI8
Gene Alias 5DIII; D3; deiodinase, iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; Dio3; DIOIII; I79_015795; iodothyronine deiodinase 3; iodothyronine deiodinase, placental type; Itdi3; LOW QUALITY PROTEIN: thyroxine 5-deiodinase; thyroxine 5-deiodinase; thyroxine deiodinase; thyroxine deiodinase type III (selenoprotein); TXDI3; Type 3 DI; type 3 iodothyronine selenodeiodinase; type III iodothyronine deiodinase; type-III 5' deiodinase; type-III 5'-deiodinase
Gene Symbols DIO3
Host Species Rabbit
Immunogen A synthesized peptide derived from human DIO3(Accession P55073), corresponding to amino acid residues V117-V141.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107585, 1735, 29475
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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