Dio3 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-5740	100 μL

Catalog No. 50-198-5740 Supplier Bioss Supplier No. BS3902R

Description

Rabbit Polyclonal Antibody

DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3′,5-triiodothyronine (T3) to inactive metabolites, 3,3′,5′-triiodothyronine (RT3) and 3,3′-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3′ UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Specifications

• Antigen: Dio3
• Applications: ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: DIO3
• Gene Accession No.: P55073
• Gene Alias: 5DIII; D3; deiodinase, iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; Dio3; DIOIII; I79_015795; iodothyronine deiodinase, placental type; ITDI3; Thyroxine 5-deiodinase; thyroxine deiodinase type III (selenoprotein); Txdi3; Type 3 DI; type 3 iodothyronine selenodeiodinase; Type III iodothyronine deiodinase; type-III 5′ deiodinase; type-III 5′-deiodinase
• Gene Symbols: DIO3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Dio3.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1735
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG