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Invitrogen™ Diphtheria Toxin Polyclonal Antibody, Biotin
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Catalog No. PIPA173139
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PIPA173139 1 mL
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Catalog No. PIPA173139 Supplier Invitrogen™ Supplier No. PA173139
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Description

Goat Polyclonal Antibody

The PA1-73139 antibody reacts with Diphtheria toxin. PA1-73139 has been successfully used in Immunohistochemical, ELISA, Immunofluorescence and Western blot applications. The PA1-73139 antibody was raised against purified diphtheria toxoid.

Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae. The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis. The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution. The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a transmembrane (TM) domain, which consists of 9 alpha-helices, 2 pairs of which may participate in pH-triggered membrane insertion and translocation; and a receptor-binding domain, which forms a flattened beta-barrel with a jelly-roll-like topology. The TM- and receptor binding-domains together constitute fragment B.
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Specifications

Antigen Diphtheria Toxin
Applications ELISA, Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 5.0 mg/mL
Conjugate Biotin
Formulation PBS with 0.1% sodium azide; pH 7.2
Gene Alias DT
Host Species Goat
Immunogen Purified diphtheria toxoid.
Purification Method IgG fraction
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Bacteria
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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