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Invitrogen™ DIS3 Polyclonal Antibody
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Catalog No. PIPA5100140
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PIPA5100140 100 μL
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Catalog No. PIPA5100140 Supplier Invitrogen™ Supplier No. PA5100140
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DIS3.

The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DIS3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DIS3
Gene Accession No. Q9CSH3, Q9Y2L1
Gene Alias 2810028N01Rik; bA555G22.1; DIS3; DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog; DIS3 mitotic control homolog (S. cerevisiae); dis3p; EXOSC11; exosome complex exonuclease RRP44; exosome component 11; KIAA1008; mitotic control protein dis3 homolog; protein DIS3 homolog; RGD1304646; Ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44
Gene Symbols DIS3
Host Species Rabbit
Immunogen A synthesized peptide derived from human DIS3(Accession Q9Y2L1), corresponding to amino acid residues L736-I786.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22894, 306103, 72662
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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