DIS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9643	Proteintech Group Inc 146891AP150UL	150 μL

Description

The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

Specifications

• Antigen: DIS3
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q9CSH3, Q9Y2L1
• Gene ID (Entrez): 22894, 306103, 72662
• Immunogen: DIS3 Fusion Protein Ag6117
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: DIS3

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: DIS3, dis3p, EXOSC11, KIAA1008, Protein DIS3 homolog, RP11 342J4.3, RRP44
• Gene Symbols: Dis3
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody