DISP2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1495	100 μL

Catalog No. 50-198-1495 Supplier Bioss Supplier No. BS11588R

Description

Rabbit Polyclonal Antibody

Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.

Specifications

• Antigen: DISP2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: DISP2
• Gene Accession No.: A7MBM2
• Gene Alias: AI840597; B230210L08Rik; C15orf36; DISP2; dispatched B; dispatched homolog 2; dispatched homolog 2 (Drosophila); dispatched RND transporter family member 2; DISPB; HsT16908; KIAA1742; LINC00594; mKIAA1742; Protein dispatched homolog 2
• Gene Symbols: DISP2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human DISP2 .
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 85455
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG