Invitrogen™ DKK1 Monoclonal Antibody (259631)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523958

Catalog No. PIMA523958

Description

This antibody does not cross-react with recombinant human Dkk-1, -3, or -4. Reconstitute at 0.5 mg/mL in sterile PBS.

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.

Specifications

• Antigen: DKK1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O54908
• Gene Symbols: DKK1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Dkk-1 Ser30-His272.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Frozen), Western Blot
• Clone: 259631
• Conjugate: Unconjugated
• Gene: DKK1
• Gene Alias: dickkopf 1 homolog; dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; Dickkopf1; dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK1; DKK-1; hDkk1; hDkk-1; mdkk-1; SK; UNQ492/PRO1008
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 13380
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized