Invitrogen™ DKK1 Monoclonal Antibody (2H2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515497

Catalog No. PIMA515497

Description

MA5-15497 targets DKK1 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15497 immunogen is purified recombinant fragment of DKK1 expressed in E. Coli. MA5-15497 detects DKK1 which has a predicted molecular weight of approximately 28.7kDa.

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.

Specifications

• Antigen: DKK1
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: O94907
• Gene Symbols: DKK1
• Immunogen: Purified recombinant fragment of DKK1 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 22943
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot
• Clone: 2H2
• Conjugate: Unconjugated
• Gene: DKK1
• Gene Alias: dickkopf 1 homolog; dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; Dickkopf1; dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK1; DKK-1; hDkk1; hDkk-1; mdkk-1; SK; UNQ492/PRO1008
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov