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Invitrogen™ DKK1 Monoclonal Antibody (2H2)
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Catalog No. PIMA515497
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100 μL
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PIMA515497 100 μL
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Catalog No. PIMA515497 Supplier Invitrogen™ Supplier No. MA515497
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Description

Mouse Monoclonal Antibody

MA5-15497 targets DKK1 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15497 immunogen is purified recombinant fragment of DKK1 expressed in E. Coli. MA5-15497 detects DKK1 which has a predicted molecular weight of approximately 28.7kDa.

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DKK1
Applications ELISA, Western Blot
Classification Monoclonal
Clone 2H2
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene DKK1
Gene Accession No. O94907
Gene Alias dickkopf 1 homolog; dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; Dickkopf1; dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK1; DKK-1; hDkk1; hDkk-1; mdkk-1; SK; UNQ492/PRO1008
Gene Symbols DKK1
Host Species Mouse
Immunogen Purified recombinant fragment of DKK1 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22943
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

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