Invitrogen™ DKK3 Monoclonal Antibody (8A5C6)

Catalog No.	Quantity
PIMA517067	100 μg

Catalog No. PIMA517067 Supplier Invitrogen™ Supplier No. MA517067

Description

Mouse Monoclonal Antibody

MA5-17067 targets DKK3 in FACS, IHC, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17067 immunogen is purified recombinant fragment of human DKK3 (amino acids: 91-350 ) expressed in E. Coli. MA5-17067 detects DKK3 which has a predicted molecular weight of approximately 38.3kDa.

DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.

Specifications

• Antigen: DKK3
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 8A5C6
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide
• Gene: DKK3
• Gene Accession No.: Q9UBP4
• Gene Alias: AW061014; C87148; Dickkopf; dickkopf 3; dickkopf 3 homolog; Dickkopf gene 3; dickkopf homolog 3; dickkopf homolog 3 (Xenopus laevis); dickkopf WNT signaling pathway inhibitor 3; Dickkopf3; dickkopf-3; Dickkopf-related protein 3; DKK 3; Dkk3; dkk-3; hDkk 3; hDkk-3; hhDkk3; mDkk-3; p29; regulated in glioma; Reic; RIG; RIG-like 5-6; RIG-like 7-1; UNQ258/PRO295; Xenopus
• Gene Symbols: DKK3
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human DKK3 (amino acids: 91-350 ) expressed in E. Coli.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27122
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1