Invitrogen™ DKK3 Recombinant Rabbit Monoclonal Antibody (1R5E0)

Catalog No.	Quantity
PIMA535416	100 μL

Catalog No. PIMA535416 Supplier Invitrogen™ Supplier No. MA535416

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: TRGSNGTICD NQRDCQPGLC CAFQRGLLFP VCTPLPVEGE LCHDPASRLL DLITWELEPD GALDRCPCAS GLLCQPHSHS LVYVCKPTFV GSRDQDGEIL LPREVPDEYE VGSFMEEVRQ ELEDLERSLT EEMALREPAA AAAALLGGEE I.

DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.

Specifications

• Antigen: DKK3
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 1R5E0
• Concentration: 0.41 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: DKK3
• Gene Accession No.: Q9QUN9, Q9UBP4
• Gene Alias: AW061014; C87148; Dickkopf; dickkopf 3; dickkopf 3 homolog; Dickkopf gene 3; dickkopf homolog 3; dickkopf homolog 3 (Xenopus laevis); dickkopf WNT signaling pathway inhibitor 3; Dickkopf3; dickkopf-3; Dickkopf-related protein 3; DKK 3; Dkk3; dkk-3; hDkk 3; hDkk-3; hhDkk3; mDkk-3; p29; regulated in glioma; Reic; RIG; RIG-like 5-6; RIG-like 7-1; UNQ258/PRO295; Xenopus
• Gene Symbols: DKK3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-350 of human DKK3 (Q9UBP4) (NP_056965.3).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 171548, 27122, 50781
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG