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  5. Tocris Bioscience™ DL 175

Tocris Bioscience™ DL 175
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Catalog No. 708210
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Catalog No. Quantity
70-821-0 10 mg
70-825-0 50 mg
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Catalog No. 70-821-0 Supplier Tocris Bioscience™ Supplier No. 7082/10
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Description

Potent and selective GPR84 agonist

DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

Specifications

Chemical Name or Material 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Quantity 10 mg
Target Free Fatty Acid Receptor Agonists
Molecular Formula C17H14ClNO2
Formula Weight 1263
Purity 98%
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