Tocris Bioscience™ DL-AP5 Sodium salt

Description

Potent and selective NMDA antagonist; sodium salt of DL-AP5

DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.

DL mixture, D-isomer and L-isomer also available.

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Specifications

• Quantity: 50 mg
• Product Type: DL-AP5 Sodium salt
• Purity: >98%
• Molecular Weight (g/mol): 219.11
• Inhibitors: DL-AP5 Sodium salt

For Research Use Only