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DLG3 Monoclonal Antibody (OTI3F2), TrueMAB™, OriGene
SDP

Catalog No. 501673268
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50-167-3268 100 μL
50-254-1728 30 μL
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Catalog No. 50-167-3268 Supplier OriGene Supplier No. TA502190
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Description

Mouse Monoclonal Antibody

Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three ∽90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

Specifications

Antigen DLG3
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone OTI3F2
Concentration 0.96 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene DLG3
Gene Accession No. Q92796
Gene Alias MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR
Gene Symbols DLG3
Host Species Mouse
Immunogen Full length human recombit protein of human DLG3 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1741
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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