Invitrogen™ DLL3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523448

Catalog No. PIPA523448

Description

Sequence homology: Cat (83%), Bovine (81%), Mouse, Rat (72%).

Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway. It inhibits primary neurogenesis. DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1). Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence. It may be required to divert neurons along a specific differentiation pathway.

Specifications

• Antigen: DLL3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dll3
• Gene Alias: delta like canonical Notch ligand 3; Delta3; delta-like 3; delta-like 3 (Drosophila); delta-like protein 3; Dll3; Drosophila Delta homolog 3; M-Delta-3; pu; pudgy; SCDO1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 10683, 13389
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: O88516, Q9NYJ7
• Gene Symbols: Dll3
• Immunogen: A portion of amino acid 100 to 150 of human DLL3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Monkey
• Product Type: Antibody
• Isotype: IgG