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Invitrogen™ DLL4 (delta-like 4) Monoclonal Antibody (HMD4-2), PE
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Catalog No. PIMA528212
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100 Tests
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Catalog No. Quantity
PIMA528212 100 Tests
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Catalog No. PIMA528212 Supplier Invitrogen™ Supplier No. MA528212
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Description

Hamster Monoclonal Antibody

Reconstitute with 1.0 mL distilled water. Vial contains sample for 100 tests per 1 mL Hamster anti Mouse Delta-Like Protein 4 antibody, clone HMD4-2 recognizes mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
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Specifications

Antigen DLL4 (delta-like 4)
Applications Flow Cytometry
Classification Monoclonal
Clone HMD4-2
Concentration Conc. not determined
Conjugate PE
Formulation PBS with 1% BSA, 5% sucrose and 0.09% sodium azide
Gene Dll4
Gene Accession No. Q9JI71
Gene Alias AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341
Gene Symbols Dll4
Host Species Hamster
Immunogen Recombinant mouse DLL4.
Purification Method Protein G
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54485
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Lyophilized
Isotype IgG
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