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Invitrogen™ DLL4 (delta-like 4) Monoclonal Antibody (MHD4-46)
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Catalog No. PIMA528625
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100 μg
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Catalog No. Quantity
PIMA528625 100 μg
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Catalog No. PIMA528625 Supplier Invitrogen™ Supplier No. MA528625
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Description

Mouse Monoclonal Antibody

This antibody recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development. Functional Application: Blocking.

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
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Specifications

Antigen DLL4 (delta-like 4)
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
Clone MHD4-46
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene Dll4
Gene Accession No. Q9NR61
Gene Alias AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341
Gene Symbols Dll4
Host Species Mouse
Immunogen recombinant soluble human DLL4.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54567
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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