Invitrogen™ DLL4 Monoclonal Antibody (4A11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA517068

Catalog No. PIMA517068

Description

MA5-17068 targets DLL4 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. This product is derived from clone #4A11F8 Mouse IgG2b and clone #4A11G2 Mouse IgG1 The MA5-17068 immunogen is purified recombinant fragment of human DLL4 expressed in E. Coli. MA5-17068 detects DLL4 which has a predicted molecular weight of approximately 74.6kDa.

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

Specifications

• Antigen: DLL4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q9NR61
• Gene Symbols: Dll4
• Immunogen: Purified recombinant fragment of human DLL4 expressed in E. Coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1, IgG2b

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 4A11
• Conjugate: Unconjugated
• Gene: Dll4
• Gene Alias: AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 54567
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid